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CAS 841205-47-8 SARMS Raw Powder Ibutamoren MK-677 For Muscle Enhancement
Synonyms: Ibutamoren;2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide;IbutaMoren (MK-677)
CAS No.: 159634-47-6
Molecular formula: C27H36N4O5S
Molecular Weight: 528.67
MK-677 is an selective agonist of the gherlin receptor and a growth hormone secretagogue stimulating the growth hormone. Studies have shown to sustain activation of GH-IGF-1, increase in lean body mass and bone mineral density.
MK-677 is so great because it increases growth hormone levels but doesn’t increase in other hormones such as cortisol.
Ibutamoren is frequently discussed on online forums for its muscle-building properties. It is available over the counter and used by those wishing to increase their growth hormone levels.
However, clinical studies of this compound are relatively few. In the text below, we will highlight what is known about ibutamoren so far.
Ibutamoren (also known as ibutamoren mesylate or MK-677), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) [R, R].
Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.
GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition [R]. Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite – and as expected, like ghrelin, ibutamoren increases it.
A great thing about ibutamoren is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol [R, R]. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.
An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist.
Usage An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
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