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Drostanolone Propionate is an anabolic androgenic steroid that first hit the market around 1970 under the trade name Masteron manufactured by Syntex. However, the compound was actually developed by Syntex in 1959 along with Oxymetholone (Anadrol) but would not be released until well after Anadrol. Syntex would also provide the compound under numerous other brand names such as Masteril and Metormon among others, as well as Drolban under the license given by Syntext to Lilly. However, Masteron has remained the most recognizable brand.
Masteron is a powerful anabolic/androgenic steroid derived from DHT that was designed to fight certain forms of breast cancer. It is used by bodybuilders as a bulking and cutting agent, as well as an ancillary drug to combat estrogenic side effects like water-retention. Its toxicity to the liver is very low, although side effects such as acne, hair loss and prostrate enlargement are common.
Masteron is an injectable preparation containing the steroid drostanolone propionate. Drostanolone is a derivative of dihydrotestosterone, most specifically 2alpha-methyldihydrotestosterone. As a result, the structure of this steroid is that of a moderate anabolic/potent androgen which does not aromatize to estrogen. Water retention and gynecomastia therefore do not come into play with this drug. Masteron may in fact exhibit anti-estrogenic activity in the body, competing with other substrates for binding to aromatase. This would reduce the conversion rate of other steroids, Masteron acting in the same way as the oral steroid Proviron.
Masteron Compares to Other Steroids
Many have called Masteron a “weak” steroid, but this definitely is not the case. What often has been weak has been the doses! Doses of this drug have historically been low because of rarity, price, and low concentration of the preparations (100 mg/mL.) However, both availability and price have improved markedly in recent years.
When included as part of a steroid stack, Masteron’s contribution per milligram is at least as great as that of testosterone, boldenone (Equipoise), nandrolone (Deca), or methenolone (Primobolan.) But of course, if only 100 or 200 mg is added per week, there will be no large change seen from such a small addition.
Masteron can be used as the sole injectable: in this case, I prefer to see dosing of 500-700 mg/week. A Masteron/Dianabol stack is more effective however, as is a Masteron/Anadrol stack. Testosterone also combines well with Masteron.
Another use of Masteron which has become more common lately is combination with trenbolone. Unlike combination with Dianabol or Anadrol, there is only an additive effect, not a synergistic effect. However, including Masteron allows a lower trenbolone dosage while achieving very similar or equal physique benefit with less potential for trenbolone-specific side effects of night-sweats, increased tendency to aggression, and/or insomnia.
Masteron also is useful in combination with testosterone for self-prescribed hormone-replacement therapy (HRT.) For example, 100 mg/week each of Masteron and testosterone can be superior for physique benefits to 200 mg/week testosterone alone, while being milder in side effects due to lower resulting levels of estradiol (estrogen) and DHT.
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