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CAS 98319-26-7 Pharmaceuticals Raw Materials Finasteride for Hair Growth
Finasteride (Steroids) Spec.
English Synonyms: PROSCAR;PROSTIDE;MK-906
CAS NO.: 98319-26-7
Packing:foil bag or as require
Appearance: White or white crystalline solid. Soluble in chloroform, dimethyl sulfoxide, ethanol, methanol or propanol, insoluble in propylene glycol or polyethylene glycol 400
Usage: The drug can be very effective in reducing blood and dihydro testosterone within the prostate. Finasteride no affinity to the androgen receptor
Physicians sometimes use finasteride for the treatment of BPH, informally known as an enlarged prostate. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow. It provides less symptomatic relief than alpha-1 blockers such as tamsulosin and symptomatic relief is slower in onset (six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment). Symptomatic benefits are mainly seen in those with prostate volume > 40 cm3. In long-term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention (−57% at 4 years) and the need for surgery (−54% at 4 years). If the drug is discontinued, any therapeutic benefits reverse within about 6-8 months.
|Test Items||Specification||Test Results|
|Description||White or off-white crystalline powder||Off-white crystalline powder|
|Identification||IR||Matches with working standard||Complies|
|Solubility||Freely soluble in chloroform and in alcohol||Conform|
|Very slightly soluble in water|
|Residue on ignition||≤0.1%||0.05%|
|Relative material||Maximum impurities≤0.5%||0.36%|
Finasteride works by blocking the conversion of the hormone testosterone to dihydrotestosterone in the prostate. It does this by blocking an enzyme called 5-alpha reductase. Dihydrotestosterone is partly responsible for making the prostate enlarge.
Therefore a reduced amount of dihydrotestosterone in the prostate causes it to shrink. This helps you to pass urine more easily.
Physicians use finasteride for the treatment of benign prostatic hyperplasia (BPH), informally known as an enlarged prostate. The FDA-approved dose is 5 mg once a day. Six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment.
If the drug is discontinued, any therapeutic benefits reverse within about 6–8 months. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow.