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AICAR / Acadesine Sarms Powder Pharmaceutical Anabolic Steroids CAS 2627-69-2

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AICAR / Acadesine Sarms Powder Pharmaceutical Anabolic Steroids CAS 2627-69-2

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AICAR / Acadesine Sarms Powder Pharmaceutical Anabolic Steroids CAS 2627-69-2 supplier AICAR / Acadesine Sarms Powder Pharmaceutical Anabolic Steroids CAS 2627-69-2 supplier AICAR / Acadesine Sarms Powder Pharmaceutical Anabolic Steroids CAS 2627-69-2 supplier

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Product Details:

Place of Origin: Hubei, China
Brand Name: Mking
Certification: GMP, ISO 9001, USP
Model Number: CAS 2627-69-2

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiate
Packaging Details: Foil bag
Delivery Time: In 24 hours
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg/Month
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Detailed Product Description
Appearance: White Crystalline Powder Purity: 99% Min
Type: Raw Sarms Powder Grade: Medical Grade
Application: Research Test Method: HPLC
Express: Fedex UPS EMS DHL TNT HKEMS EUB Delivery: Door To Door, 7 Days

 

Pharmaceutical Raw Materials AICAR / Acadesine Sarms Powder CAS 2627-69-2

 

AICAR Quick Detail


Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

 

AICAR Description


AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects. Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.

 

AICAR Functions


AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

Pharmaceutical Grade Hot Sell Raw Sarms


Acetamidoxolutamide (SARMS S-4)
MK-2866 (Ostarine, OSTA-SARMS)
GW-50, GW-501516, Cardarine, GSK-516
MK-677 (Nutrobal)
LGD-4033 (Anabolicum)
RAD-140
SR-9009
Aicar
YK-11
 

Pharmaceutical Grade Hot Sell Finished Sarms

 

SARMS Product Name Standard, 100 tabs/bottle
Ibutamoren mesylate MK677,M7 10mg
Ligandrol/LGD-4033 10mg
SR9009 10mg
RAD-140 10mg
Ostarine MK-2866,Enobosarm,M2 10mg
AICAR 10mg
Andarine(S4) 10mg
Cardarine GW-501516 10mg
YK11 10mg
SARMS Product Name Standard, 50 tabs/bottle
KONG*50`s 76mg
BLACK MAGIC 111mg

 

How to proceed an order?


1st: Please let us know what you need-Which product/Cas No., quantity, and the destination country.
2nd: You send us the purchase order once we come to an agreement on all details.
3rd: Parcel would be delivered upon full payment received.
4th: Express Tracking No.will be provided about the parcels.
5th: You will get the parcels in 7-10 days.
6th: After-sales service would be provided after you receive parcels.

 

Our Advantages

 

1. Sufficient stock. We ship parcel out within 24 hours after receive the payment.

2. Safe delivery. Professional logistic agent, well-trained and disciplined packing team, 99% Customs pass rate.

3. Outstanding customer-service. Any questions or problems after receiving the products, please feel free to contact us. Problems would be solved immediately.

 

AICAR / Acadesine Sarms Powder Pharmaceutical Anabolic Steroids CAS 2627-69-2

Contact Details
Hubei Mking Biotech Co., Ltd.

Contact Person: sales

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