3000iu Erythropoietin GMP Certificated Hgh Human Growth Hormone EPO

3000iu Erythropoietin GMP Certificated Hgh Human Growth Hormone EPO

EPO is produced mainly by peritubular capillary lining cells of the renal cortex; which are highly specialized epithelial-like cells. It is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver.Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation. Constitutively synthesized transcription factors for EPO, known as hypoxia-inducible factors (HIFs), are hydroxylated and proteosomally digested in the presence of oxygen. It binds to the erythropoietin receptor (EpoR) on the red cell surface and activates a JAK2 cascade. This receptor is also found in a large number of tissues such as bone marrow cells and peripheral/central nerve cells, many of which activate intracellular biological pathways upon binding with Epo.

Features:

• Adopt full digital control technology, intelligent detection and monitoring function
• Digitally control the static switch with zero switch
• Full isolation between input and output; DC UPS isolated with utility power completely
• Super low output zero earth voltage
• Cubical design with power standard (customization)
• Multifunctional protection for overvoltage, under voltage, over current, short circuit and over temperature and so on.
• Large-screen LCD monitor with Chinese and English operation interface; Ultralong 256 event record, user-friendly analysis and management to the situation of the power supply (touch screen optional)
• Static bypass has a strong anti-overload capability
• Bypass standard features: BackFeed protection; split bypass line

Primary role in red cell blood line

Erythropoietin has its primary effect on red blood cells by promoting red blood cell survival through protecting these cells from apoptosis. It also cooperates with various growth factors involved in the development of precursor red cells. Specifically, the colony forming unit-erythroid (CFU-E) is completely dependent on erythropoietin. The burst forming unit-erythroid (BFU-E) is also responsive to erythropoietin.

Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, pro-erythroblast and basophilic erythroblast subsets in the differentiation.

It has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers. It has also been shown that erythropoietin can increase iron absorption by suppressing the hormone hepcidin.

Uses

Erythropoietin is available as a therapeutic agent produced by recombinant DNA technology in mammalian cell culture. It is used in treating anemia resulting from chronic kidney disease and myelodysplasia, from the treatment of cancer (chemotherapy and radiation). Current research suggests that, aminoacid R103 to E mutation in Erythropoietin makes it Neuroprotective and non-erythropoietic.

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