Payment & Shipping Terms:
|Appearance:||White Crystalline Powder||Purity:||99% Min|
|Type:||Raw Sarms Powder||Grade:||Medical Grade|
|Express:||Fedex UPS EMS DHL TNT HKEMS EUB||Delivery:||Door To Door, 7 Days|
AICAR / Acadesine Sarms 50mg/vial Muscle Growth Hormone CAS 2627-69-2
AICAR Quick Detail
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases
Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above. Economically, it makes most sense to run AICAR during the 4 weeks leading up to your competition.
AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects. Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
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1. We use HKEMS,EMS, Fedex, EUB and so on to deliver the goods, the clearance rate is very high and it’s safe, fast.
2. Our payment option: Western Union, Money Gram, TT, Bitcoin
3. The Min.order is 1bottle of each item, but for some highly valued products and be adjusted appropriately.
4. The packing will not contain any hormone information and be marked with other common chemical names, so that it can go through the custom smoothly.
5. We also offer the complete reshipping policy for our clients if any order seized.
6. High quality, reasonable price, first-class service, high successful delivery rate can be offered.
7. we can delivery quickly at the very day when receive the payment for we have enough goods in stock.
Packaging & Service:
1. Keep a large amount of stock to ensure timely delivery after daily payment.
2. We have been engaged in this field for many years, with excellent professional logistics department, which can ensure safe and fast delivery.
3. The well-trained and well disciplined packaging team is specialized in providing you with safe packaging. At the same time, it also avoids the occurrence of many emergencies and ensures the high pass rate. A unique way to deliver 10 g to 20 kg of powder (or 100 ml to 30 l of liquid) at a time to the destination.
4. Provide package picture and pin number within 24 hours after receiving payment for goods. Updated tracking code will be provided every other day just so you can hold your package palm.
5. Perfect after-sales service: any questions or problems after receiving the product. Please feel free to contact us. All day online to solve your problems!
Contact Person: sales